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MO-I-500
Axon 3523
CAS:
1585219-04-0
Purity:
99%
- Soluble in DMSO
- MF: C12H12ClNO5S
- MW: 317.75
Description
MO-I-500 is a FTO inhibitor with an IC50 value of is 8.7 μM for the inhibition of purified FTO demethylase catalyzing demethylation of an artificial small methylated substrate. Moreover, MO-I-500 has anticonvulsant activity in the 6 Hz mouse model at nontoxic doses, increases the amount of m6A in total cellular RNA, and modulates levels of specific miRNAs.
More Information
| Parent CAS No. | 1585219-04-0 |
|---|---|
| Chemical Name | N-(5-(4-Chlorophenyl)-3,4-dihydroxyfuran-2-yl)ethanesulfonamide |
| MFCD | N.A. |
| Short Description | FTO inhibitor |
References
- G Zheng et al. Synthesis of a FTO inhibitor with anticonvulsant activity. ACS Chem Neurosci. 2014 Aug 20;5(8):658-65.
- B Singh et al. Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS One. 2016 Jul 8;11(7):e0159072.
