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Soticlestat
- TAK935 - OV935
Axon 3485
CAS:
1429505-03-2
Purity:
100%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C23H23N3O2
- MW: 373.45
Description
Soticlestat is a potent, selective, orally active and brain-penetrant cholesterol 24-hydroxylase (CH24H; CYP46A1) inhibitor with an IC50 value of 7.4 nM.
More Information
| Parent CAS No. | 1429505-03-2 |
|---|---|
| Chemical Name | 2,4'-Bipyridin-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone |
| SMILES | N1C(C2C=CN=CC=2)=C(C(=O)N2CCC(O)(CC3C=CC=CC=3)CC2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H23N3O2/c27-22(20-7-4-12-25-21(20)19-8-13-24-14-9-19)26-15-10-23(28,11-16-26)17-18-5-2-1-3-6-18/h1-9,12-14,28H,10-11,15-17H2 |
| InChiKey | XKUZMIUSBMCVPP-UHFFFAOYSA-N |
| CID | 73437845 |
| Short Description | CYP46A1 inhibitor |
References
- T Nishi et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081.
- T Koike et al. Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J Med Chem. 2021 Aug 26;64(16):12228-12244.
