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SGC-STK17B-1
Axon 3395
CAS:
2650530-00-8
Purity:
98%
- Soluble in DMSO
- MF: C16H10N2O2S3
- MW: 358.46
Description
SGC-STK17B-1 is a potent, selective and ATP-competitive STK17B inhibitor with an IC50 value of 43 nM. SGC-STK17B-1 was developed as a high-quality chemical probe for investigating the biological functions of STK17B, a member of the death-associated protein kinase (DAPK) family.
STK17B, also known as DRAK2 (DAPK-related apoptosis-inducing protein kinase 2), is a serine/threonine kinase implicated in T-cell activation, immune regulation, apoptosis, and cancer biology. As a relatively understudied "dark kinase", STK17B has emerged as a potential therapeutic target in autoimmunity, inflammation, and cancer. SGC-STK17B-1 provides a valuable tool for studying STK17B-dependent signaling pathways and target validation in cellular systems.
Key Features
- Potent and selective STK17B inhibitor
- IC50: 43 nM
- ATP-competitive mechanism of action
- Chemical probe for the dark kinase STK17B (DRAK2)
- Useful tool for immune signaling and cancer research
Applications
- STK17B and DRAK2 biology research
- Immune signaling and T-cell function studies
- Autoimmunity and inflammatory disease research
- Cancer biology and target validation investigations
- Dark kinase and kinase signaling studies
More Information
| Parent CAS No. | 2650530-00-8 |
|---|---|
| Chemical Name | 2-(6-(Benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-ylthio)acetic acid |
| SMILES | C12C=C(C3=CC4N=CN=C(SCC(O)=O)C=4S3)SC=1C=CC=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H10N2O2S3/c19-14(20)7-21-16-15-10(17-8-18-16)6-13(23-15)12-5-9-3-1-2-4-11(9)22-12/h1-6,8H,7H2,(H,19,20) |
| InChiKey | BNYXRPMABDQJJR-UHFFFAOYSA-N |
| CID | 145994861 |
| Short Description | STK17B inhibitor |
SGC-STK17B-1
STK17B inhibitor
STK17B
DRAK2
DAPK-related apoptosis-inducing protein kinase 2
dark kinase
ATP-competitive kinase inhibitor
serine threonine kinase
DAPK family
immune signaling
T-cell activation
T-cell signaling
autoimmunity
inflammation
cancer biology
target validation
kinase signaling
hepatocellular carcinoma
breast cancer
AKT/GSK-3β/Snail signaling
CAS 2650530-00-8
Axon Medchem
Axon 3395
Enzymes
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