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Entacapone
- OR611
Axon 3389
CAS:
130929-57-6
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C14H15N3O5
- MW: 305.29
Description
Entacapone is a potent, peripherally acting, reversible inhibitor of catechol-O-methyltransferase (COMT) with IC50 values of 10 nM and 160 nM for rat duodenum and liver-soluble COMT, respectively.
More Information
| Parent CAS No. | 130929-57-6 |
|---|---|
| Chemical Name | (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide |
| SMILES | C1(O)C=C(/C=C(/C(N(CC)CC)=O)C#N)C=C([N+]([O-])=O)C=1O |
| MFCD | N.A. |
| InChi | InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+ |
| InChiKey | JRURYQJSLYLRLN-BJMVGYQFSA-N |
| CID | 5281081 |
| Short Description | COMT inhibitor |
References
- JM Cedarbaum et al. Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease. Clin Neuropharmacol. 1991 Aug;14(4):330-42.
- E Nissinen et al. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):262-6.
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