Bulk Inquiry
BI 99990
Axon 3182
CAS:
1338468-86-2
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C23H25N3O3
- MW: 391.46
Description
BI 99990 is the substantially less active enantiomer of the FASN inhibitor BI 99179 and is intended as a matched negative-control compound. Its close physicochemical relationship to BI 99179 allows experimental effects caused by FASN inhibition to be separated from scaffold-related or nonspecific responses.
BI 99990 is used in paired chemical-genetic experiments, phenotypic screening and in vivo studies as an inactive comparator for BI 99179. Results should be interpreted by confirming that the control is tested at matched concentration, exposure and formulation.
Key Features
- Matched negative-control enantiomer
- Substantially less active than BI 99179 at FASN
- Closely matched physicochemical properties
- Supports attribution of phenotypes to FASN inhibition
Applications
- FASN inhibitor control experiments
- Stereoselectivity studies
- Phenotypic-screen validation
- Matched cellular and in vivo comparator studies
The active FASN inhibitor BI 99179 is available as Axon 3181.
More Information
| Parent CAS No. | 1338468-86-2 |
|---|---|
| Chemical Name | (1S,3R)-N-(4-(Benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentanecarboxamide |
| SMILES | C1C2OC(C3C=CC(N(C([C@@H]4C[C@H](NC(CC)=O)CC4)=O)C)=CC=3)=NC=2C=CC=1 |&1:10,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H25N3O3/c1-3-21(27)24-17-11-8-16(14-17)23(28)26(2)18-12-9-15(10-13-18)22-25-19-6-4-5-7-20(19)29-22/h4-7,9-10,12-13,16-17H,3,8,11,14H2,1-2H3,(H,24,27)/t16-,17+/m0/s1 |
| InChiKey | YNFDIGJKJPNFFD-DLBZAZTESA-N |
| CID | 56678756 |
| Short Description | FAS negative control |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2617 | GSK837149A |
From $143.00 |
| 3181 | BI 99179 |
From $165.00 |
Other Categories
Get a Quote for
Loading...