Bulk Inquiry
ZT-12-037-01
Axon 2937
CAS:
2328073-61-4
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H31N5O2
- MW: 385.5
Description
ZT-12-037-01 is a specific STK19 inhibitor (IC50 value of 24 nM) which showed to effectively block oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo.
More Information
| Parent CAS No. | 2328073-61-4 |
|---|---|
| Chemical Name | N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine |
| SMILES | C1CC(NC2N=C(NC3CC3)N=C3C=C(OC)C(OC)=CC=23)CCN1C(C)C |
| MFCD | N.A. |
| InChi | InChI=1S/C21H31N5O2/c1-13(2)26-9-7-15(8-10-26)22-20-16-11-18(27-3)19(28-4)12-17(16)24-21(25-20)23-14-5-6-14/h11-15H,5-10H2,1-4H3,(H2,22,23,24,25) |
| InChiKey | AMAQJTHMSLYMFT-UHFFFAOYSA-N |
| CID | 138911316 |
| Short Description | STK19 inhibitor |
