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ZL006
Axon 2878
CAS:
1181226-02-7
Purity:
99%
- Soluble in DMSO
- MF: C14H11Cl2NO4
- MW: 328.15
Description
ZL006 blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors.
More Information
| Parent CAS No. | 1181226-02-7 |
|---|---|
| Chemical Name | 4-(3,5-Dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid |
| SMILES | C1(Cl)C(O)=C(CNC2C=C(O)C(C(=O)O)=CC=2)C=C(Cl)C=1 |
| MFCD | MFCD20527326 |
| InChi | InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21) |
| InChiKey | RTEYSQSXRFVKTJ-UHFFFAOYSA-N |
| CID | 44207238 |
| Short Description | nNOS-PSD-95 inhibitor |
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