Bulk Inquiry
STK16-IN-1
Axon 2743
CAS:
1223001-53-3
Purity:
99%
- Soluble in DMSO
- MF: C17H12FN3O
- MW: 293.3
Description
STK16-IN-1 is a highly selective ATP-competitive inhibitor which exhibits potent inhibitory activity against STK16 kinase (IC50 value of 0.295 μM). In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics results in a slight potentiation of the antiproliferative effects of the chemotherapeutics.
More Information
| Parent CAS No. | 1223001-53-3 |
|---|---|
| Chemical Name | 1-(4-Fluoro-3-methylphenyl)-1H-pyrrolo[2,3-h][1,6]naphthyridin-2(7H)-one |
| SMILES | C1(F)C(C)=CC(N2C(=O)C=CC3C=NC4NC=CC=4C2=3)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20) |
| InChiKey | WQNRDXHKVSKUPI-UHFFFAOYSA-N |
| CID | 58525066 |
| Short Description | STK16 inhibitor |
