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UNC669
- UNC0669
Axon 2163
CAS:
1314241-44-5
Purity:
99%
- Soluble in water and DMSO
- MF: C15H20BrN3O
- MW: 338.24
Description
UNC669 (UNC0669) is a small-molecule antagonist of methyl-lysine reader proteins with activity against L3MBTL1 and L3MBTL3, reported IC50 values of 4.2 µM and 3.1 µM respectively in the cited assay. It is used to study methyl-lysine recognition by malignant brain tumor (MBT) domains.
Methyl-lysine reader proteins translate histone methylation marks into chromatin-associated functional outcomes. UNC669 is relevant for epigenetic probe development and chromatin-reader selectivity studies.
Key Features
- Antagonist of methyl-lysine reader proteins
- Active against L3MBTL1 and L3MBTL3
- Targets MBT-domain chromatin recognition
- Useful epigenetic reader probe
Applications
- Chromatin reader pharmacology
- Methyl-lysine binding assays
- Epigenetic probe development
- Histone mark interpretation studies
More Information
| Parent CAS No. | 1314241-44-5 |
|---|---|
| Chemical Name | (5-bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone |
| SMILES | C(C1=CC(Br)=CN=C1)(N1CCC(N2CCCC2)CC1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2 |
| InChiKey | CQERVFFAOOUFEQ-UHFFFAOYSA-N |
| CID | 46931242 |
| Short Description | L3MBTL inhibitor |
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