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UNC1215

Axon 1994
CAS:  1415800-43-9
Purity:  99%
  • Soluble in DMSO
  • MF:  C32H43N5O2
  • MW:  529.72

Description

UNC1215 is a potent and selective L3MBTL3 methyllysine-reader antagonist with cellular activity. It is a first-in-class chemical probe for interrogating malignant brain tumor (MBT) domain methyllysine-binding proteins.

L3MBTL3 is an epigenetic reader that recognizes methylated lysine marks and contributes to chromatin-associated regulatory processes. UNC1215 is useful for studying chromatin reader biology, methyllysine recognition and epigenetic protein interactions.

Key Features

  • Selective L3MBTL3 MBT-domain antagonist
  • Cell-active methyllysine reader probe
  • First-in-class chemical probe for a Kme-binding protein
  • Useful for chromatin reader pharmacology

Applications

  • Epigenetic reader-domain assays
  • Methyllysine binding studies
  • Chromatin regulation research
  • Chemical probe validation studies

More Information

Certificate of Analysis (B2)
Material Safety Data Sheet (B2)

Certificate of Analysis

B1

Material Safety Data Sheet

B1
Parent CAS No. 1415800-43-9
Chemical Name (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)
SMILES N(C1=CC=CC=C1)C1=CC(C(N2CCC(N3CCCC3)CC2)=O)=CC=C1C(N1CCC(N2CCCC2)CC1)=O
MFCD N.A.
InChi InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChiKey PQOOIERVZAXHBP-UHFFFAOYSA-N
CID 57339144
Short Description L3MBTL3 inhibitor

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