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MALT1 inhibitor MI-2
Axon 2054
CAS:
1047953-91-2
Purity:
100%
- Soluble in DMSO
- MF: C19H17Cl3N4O3
- MW: 455.72
Description
Highly potent and selective MALT1 inhibitor; MI-2 binds directly to MALT1 and suppresses activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) in vitro and in vivo. MI-2 is notably nontoxic to mice
More Information
| Parent CAS No. | 1047953-91-2 |
|---|---|
| Chemical Name | 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide |
| SMILES | C(NC1=CC=C(N2C(C3=CC=C(Cl)C(Cl)=C3)=NC(OCCOC)=N2)C=C1)(=O)CCl |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27) |
| InChiKey | TWJGQZBSEMDPQP-UHFFFAOYSA-N |
| CID | 45942672 |
| Short Description | MALT1 inhibitor |
References
- L Fontan et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012, 22(6), 812-24.
- RM Young & LM Staudt. A New “Brew” of MALT1 Inhibitors. Cancer Cell, 2012, 22(6), 706-707.
- DJ Burgess. Anticancer drugs: Assault on MALT1. Nature Reviews Drug Discovery, 2013, 12(2), 100-101.
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