Bulk Inquiry
TAK 438
Axon 1971
- Parent CAS: 881681-00-1
Purity:
98%
- Soluble in DMSO
- MF: C17H16FN3O2S.C4H4O4
- MW: 461.46
Description
Potassium-competitive acid blocker (P-CAB); reversibly inhibits gastric H+, K+-ATPase; TAK-438 exerts a longer and more potent antisecretory effect than lansoprazole as a result of its high accumulation and slow clearance from the gastric glands
More Information
| Parent CAS No. | 881681-00-1 |
|---|---|
| Chemical Name | 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate |
| SMILES | C(O)(=O)/C=C/C(O)=O.N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(CNC)=C1 |
| MFCD | MFCD18633280 |
| InChi | InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| InChiKey | ROGSHYHKHPCCJW-WLHGVMLRSA-N |
| CID | 45375887 |
| Short Description | PCA blocker |
References
- J Matsukawa et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem. Pharmacol. 2011, 81(9), 1145-1151.
- JM Shin et al. Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (...). J. Pharmacol. Exp. Ther. 2011, 339(2), 412-420.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1695 | Digoxigenin bisdigitoxoside |
From $198.00 |
| 1826 | DBeQ |
From $99.00 |
| 1835 | CK 1827452 |
From $126.50 |
| 3161 | Pantoprazole sodium |
From $55.00 |
| 3244 | Lansoprazole |
From $44.00 |
| 3589 | Soraprazan |
From $154.00 |
| 3663 | Rabeprazole sodium |
From $55.00 |
| 4039 | CB-103 |
From Inquiry |
Other Categories
Get a Quote for
Loading...