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Vasopressin antagonist 1867
- Compound 12i
Axon 1867
CAS:
909391-88-4
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C28H36N4O4
- MW: 492.61
Description
Vasopressin antagonist 1867 (Compound 12i) is an orally available, selective vasopressin V1B receptor antagonist with a reported IC50 value of 3 nM at human V1B receptors.
V1B receptors regulate pituitary corticotroph function and stress-induced ACTH release within the hypothalamic-pituitary-adrenal axis. Vasopressin antagonist 1867 is useful for studying neuroendocrine stress responses and V1B receptor selectivity.
Key Features
- Potent vasopressin V1B receptor antagonist
- IC50: 3 nM for human V1B inhibition
- More than 1000-fold selective over V1A, V2 and oxytocin receptors
- Orally available neuroendocrine pharmacology tool
Applications
- V1B receptor binding and functional assays
- HPA-axis and ACTH release studies
- Stress-response and neuroendocrine research
- Vasopressin receptor selectivity profiling
More Information
| Parent CAS No. | 909391-88-4 |
|---|---|
| Chemical Name | N-isopropyl-2-(2-(3-methoxyphenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)acetamide |
| SMILES | N1C2=C(C=C(OCCCN3CCCCC3)C=C2)C(=O)N(CC(NC(C)C)=O)C=1C1=CC=CC(OC)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C28H36N4O4/c1-20(2)29-26(33)19-32-27(21-9-7-10-22(17-21)35-3)30-25-12-11-23(18-24(25)28(32)34)36-16-8-15-31-13-5-4-6-14-31/h7,9-12,17-18,20H,4-6,8,13-16,19H2,1-3H3,(H,29,33) |
| InChiKey | NQOZPTYIJQUKTJ-UHFFFAOYSA-N |
| CID | 11677610 |
| Short Description | V1b antagonist |
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