Chloride
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ABC (ATP-binding cassette) transporter-class ion channel that transports chloride and thiocyanate ions across epithelial cell membranes[1]. Like the P2X receptors, the CFTR has an ATP binding domain, and is considered a cAMP-activated ATP-gated anion channel. It is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, reproductive tract, and skin. Chloride transport through the CFTR channel works in concert with sodium transport through epithelial sodium channels (ENaC) to maintain salt, fluid, and pH homeostasis in various epithelial tissues. Mutations of the CFTR gene affect functioning of the chloride ion channels in these cell membranes, leading to cystic fibrosis and congenital absence of the vas deferens[2].
[1] The ABC protein turned chloride channel whose failure causes cystic fibrosis. D.C. Gadsby, P. Vergani, L. Csanády. Nature 2006, 440, 477-483.
[2] Cystic fibrosis transmembrane regulator protein mutations: 'class' opportunity for novel drug innovation. K.D. MacDonald, K.R. McKenzie, P.L.Zeitlin. Paediatr. Drugs 2007, 9, 1-10.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2552 | Adjudin | Non-hormonal male contraceptive with anti-proliferative activity | €125.00 | |
| 4049 | Ataluren | CFTR-G542X suppressor | Recently added | €110.00 |
| 1763 | CoPo 22 | Modulator of CFTR (δ-F508 Selective) | €120.00 | |
| 2572 | GlyH 101 | Highly potent and selective CFTR inhibitor | €105.00 | |
| 3234 | Lumacaftor | Selective and orally bioavailable CFTR corrector | €70.00 | |
| 2295 | PPQ 102 | CFTR inhibitor that acts by a mechanism involving stabilization of the channel closed-state | €100.00 | |
| 2169 | VX 661 | Corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) | €80.00 | |
| 2503 | VX 770 | Orally bioavailable CFTR potentiator | €125.00 | |