VX 661 - Tezacaftor

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2169

CAS [1152311-62-0]

MF C26H27F3N2O6
MW 520.50

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

VX 661

Description

Corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), hypothesized to restore F508del mutation processing and plasma membrane localization of CFTR protein, thereby effectively increasing functional surface CFTR ion channels. VX 661 is the second CFTR corrector in line with VX 809 (first), and VX 983 (third), and is believed to help CFTR protein reach the cell surface.

Tested in phase 2 to evaluate safety, efficacy, pharmacokinetics, and pharmacodynamics in subjects with cystic fibrosis suffering from the F508del-CFTR mutation.

Order
Size Unit Price Stock
5 mg €115.00 In Stock
25 mg €385.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €180.00 In Stock
2 x 25 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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