VX 661 - Tezacaftor

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2169

CAS [1152311-62-0]

MF C26H27F3N2O6
MW 520.50

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

VX 661

Description

Corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), hypothesized to restore F508del mutation processing and plasma membrane localization of CFTR protein, thereby effectively increasing functional surface CFTR ion channels. VX 661 is the second CFTR corrector in line with VX 809 (first), and VX 983 (third), and is believed to help CFTR protein reach the cell surface.

Tested in phase 2 to evaluate safety, efficacy, pharmacokinetics, and pharmacodynamics in subjects with cystic fibrosis suffering from the F508del-CFTR mutation.

Vertex Pharmaceuticals Incorporated. Study of VX-661 Alone and in Combination With VX-770 in Subjects Homozygous to the F508del-CFTR Mutation. ClinicalTrials.gov [Online]. 2012.

A. Opar. Excitement mounts for first disease-modifying cystic fibrosis drugs. Nat. Rev. Drug. Discov. 2011, 10, 479-480.

Corrector of the cystic fibrosis transmembrane conductance regulator (CFTR)

Chemical name

(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

Parent CAS No.

[1152311-62-0]

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Size	Unit Price	Stock
5 mg	€80.00	In Stock
25 mg	€240.00	In Stock

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2 x 5 mg	€120.00	In Stock
2 x 25 mg	€360.00	In Stock

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2572	GlyH 101	Highly potent and selective CFTR inhibitor	€105.00
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VX 661 - Tezacaftor

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VX 661 - Tezacaftor

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