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ABT-491 hydrochloride
- A137491 hydrochloride
Axon 4441
- Parent CAS: 170499-15-7
Purity:
98%
- Soluble in water and DMSO
- MF: C28H22FN5O2·HCl
- MW: 515.97
Description
ABT-491 hydrochloride is a highly potent, water-soluble, orally active, and long-acting PAF receptor antagonist with a Ki value of 0.6 nM. Administration of ABT-491 in vivo leads to potent inhibition of PAF-induced inflammatory responses (increased vascular permeability, hypotension, and edema) and PAF-induced lethality. Water soluble hydrochloride salt of ABT-491 (Axon 4480, parent molecule).
More Information
| Parent CAS No. | 170499-15-7 |
|---|---|
| Chemical Name | N,N-Dimethyl-4-ethynyl-3-(3-fluoro-4-((2-methyl-1,3,5-triaza-1H-inden-1-yl)methyl)benzoyl)-1-indolecarboxamide hydrochloride |
| SMILES | C1=CC(CN2C(C)=NC3=CN=CC=C23)=C(F)C=C1C(=O)C1=CN(C(N(C)C)=O)C2=CC=CC(C#C)=C12.Cl |
| MFCD | MFCD00945301 |
| InChi | InChI=1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H |
| InChiKey | AWRGBOKANQBIBM-UHFFFAOYSA-N |
| CID | 154086 |
| Short Description | PAF antagonist |
References
- DH Albert et al. Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist. Eur J Pharmacol. 1997 Apr 23;325(1):69-80.
- ML Curtin et al. Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem. 1998 Jan 1;41(1):74-95.
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