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ABT-491
- A137491
Axon 4480
CAS:
170499-15-7
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C28H22FN5O2
- MW: 479.51
Description
ABT-491 is a highly potent, orally active, and long-acting PAF receptor antagonist with a Ki value of 0.6 nM. Administration of ABT-491 in vivo leads to potent inhibition of PAF-induced inflammatory responses (increased vascular permeability, hypotension, and edema) and PAF-induced lethality. ABT-491 is also available as the water soluble HCl salt (Axon 4441).
More Information
| Parent CAS No. | 170499-15-7 |
|---|---|
| Chemical Name | N,N-Dimethyl-4-ethynyl-3-(3-fluoro-4-((2-methyl-1,3,5-triaza-1H-inden-1-yl)methyl)benzoyl)-1-indolecarboxamide |
| Short Description | PAF antagonist |
References
- DH Albert et al. Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist. Eur J Pharmacol. 1997 Apr 23;325(1):69-80.
- ML Curtin et al. Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem. 1998 Jan 1;41(1):74-95.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4441 | ABT-491 hydrochloride |
From $187.00 |
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