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Golgicide A
- GCA
Axon 4197
CAS:
1139889-93-2
- Optical Purity: 96% d.e.
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C17H14F2N2
- MW: 284.3
Description
Golgicide A is a potent, highly specific, rapidly reversible inhibitor of the cis-Golgi ArfGEF GBF1. Inhibition of GBF1 function resulted in rapid dissociation of COPI vesicle coat from Golgi membranes and subsequent disassembly of the Golgi and trans-Golgi network.
More Information
| Parent CAS No. | 1139889-93-2 |
|---|---|
| Chemical Name | rel-(3aR,9bS)-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline |
| SMILES | [C@@]12([H])CC=C[C@]1([H])C1C=C(F)C=C(F)C=1NC2C1C=CC=NC=1 |&1:0,5,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | GBF1 inhibitor |
