IGGi-11me - IGGi-11 prodrug

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 4160

CAS [N.A.]

MF C25H32N2O8S2
MW 552.66

  • Purity: 98%
  • Soluble in DMSO
Recently added

IGGi-11me

Description

IGGi-11me is a membrane permeable prodrug of IGGi-11, which is the first-in-class inhibitor of noncanonical activation of heterotrimeric G-protein signaling. IGGi-11 binding to G-protein α-subunits (Gαi) specifically disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer cells.

The membrane permeability of IGGi-11me was higher than that of IGGi-11. The esterase in the cytoplasm of MDA-MB-231 cells could convert IGGi-11me into IGGi-11. Thus, IGGi-11me acts as a prodrug, allowing IGGi-11 to function in cells much better.

KEYWORDS: IGGi-11me | Supplier | GIV-Gαi inhibitor | IGGi-11 prodrug | IGGi11me | IGGi 11me | GLXC27028 | GLXC 27028 | GLXC-27028 | CAS [N.A.] | GPCR-independent noncanonical G-protein signaling | Inhibitor | Enzymes | Heterotrimeric G-protein | GIV | Girdin | Tumor | Gα subunit

Order
Size Unit Price Stock
5 mg €140.00 In Stock
25 mg €560.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...