PF-06281355 - PF1355

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 3992

CAS [1435467-38-1]

MF C14H15N3O4S
MW 321.35

  • Purity: 99%
  • Soluble in DMSO



PF-06281355 is a selective, orally active, mechanism-based myeloperoxidase (MPO) inhibitor, efficacious in cell assays and in vivo. Oral administration of PF-06281355 reduced plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction were completely suppressed by PF-06281355 treatment.

KEYWORDS: PF-06281355 | Supplier | MPO inhibitor | PF1355 | PF-1355 | PF 1355 | PF06281355 | PF 06281355 | CAS [1435467-38-1] | Hydrogen peroxide | Chloride | Myeloperoxidase | Inhibitor | Enzymes | Small vessel vasculitis

Size Unit Price Stock
5 mg €80.00 In Stock
25 mg €240.00 In Stock
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Size Unit Price Stock
2 x 5 mg €120.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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