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Axon 3992
CAS [1435467-38-1]
MF C14H15N3O4SMW 321.35
PF-06281355 is a selective, orally active, mechanism-based myeloperoxidase (MPO) inhibitor, efficacious in cell assays and in vivo. Oral administration of PF-06281355 reduced plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction were completely suppressed by PF-06281355 treatment.
KEYWORDS: PF-06281355 | Supplier | MPO inhibitor | PF1355 | PF-1355 | PF 1355 | PF06281355 | PF 06281355 | CAS [1435467-38-1] | Hydrogen peroxide | Chloride | Myeloperoxidase | Inhibitor | Enzymes | Small vessel vasculitis
2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
[1435467-38-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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