Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3881

CAS [860456-56-0]

MF C18H17NO5
MW 327.33

  • Purity: 99%
  • Soluble in DMSO and EtOH



ECSI#6 is the first uncompetitive serotonin transporter (SERT) inhibitor. Inhibition of serotonin uptake by ECSI#6 was enhanced with increasing serotonin concentration. Conversely, the KM for serotonin was lowered by augmenting ECSI#6. ECSI#6 bound with low affinity to the outward-facing state of SERT but with increased affinity to a potassium-bound state. ECSI#6 also acted as a pharmacochaperone: cellular preincubation with ECSI#6 restored export from the endoplasmic reticulum (ER) and substrate transport by a misfolded SERT variant.

KEYWORDS: ECSI#6 | SERT inhibitor | CAS [860456-56-0] | Serotonin |SERT | Inhibitor | Proteins

First uncompetitive serotonin transporter (SERT) inhibitor

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €140.00 In Stock
25 mg €560.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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