C28 is a potent LMTK3 inhibitor with an IC50 value of 67 nM. Pharmacologic inhibition of LMTK3 decreases proliferation of cancer cell lines in the NCI-60 panel, with a concomitant increase in apoptosis in breast cancer cells, recapitulating effects of LMTK3 gene silencing. Furthermore, LMTK3 inhibition reduces growth of xenograft and transgenic breast cancer mouse models without displaying systemic toxicity at effective doses.

KEYWORDS: LMTK3 inhibitor C28 | Supplier | LMTK3 inhibitor | C 28 | C-28 | CAS [2764850-23-7] | Non Selective (Phosphorylation substrates) | LMTK | Inhibitor | Enzymes | Heat shock protein 90 client protein | HSP90 | LMR3 | AATYK3 | Breast cancer