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Axon 3639

CAS [2376297-69-5]

MF C26H26N4O3S
MW 474.57

  • Purity: 98%
  • Soluble in DMSO



PTX80 is a first-in-class inhibitor of protein degradation by targeting the autophagy receptor p62/SQSTM1. PTX80 binds to p62, inducing a decrease in soluble p62 and formation of insoluble p62 aggregates, and failure of polyubiquitinated proteins to colocalize with p62. PTX80 induces proteotoxic stress and activation of unfolded protein response, which, in turn, leads to apoptosis.

KEYWORDS: PTX80 | p62/SQSTM1 ligand | PTX 80 | PTX-80 | CAS [2376297-69-5] | [2376297-70-8] | [2376297-71-9] | Ubiquitin | Inhibitor | Proteins | Sequestosome 1 | UPR

First-in-class inhibitor of protein degradation by targeting p62/SQSTM1

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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