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NAV-2729
- Grassofermata
Axon 3622
CAS:
419547-11-8
Purity:
99%
- Soluble in DMSO
- MF: C25H17ClN4O3
- MW: 456.88
Description
NAV-2729 is a dual Arf1/Arf6 inhibitor and is more effective towards Arf1 than Arf6. Moreover, NAV-2729 is an inhibitor of human FATP2 with a Ki value of 17.18 μM for inhibition of C1-BODIPY-C12 uptake into Caco-2 cells.
More Information
| Parent CAS No. | 419547-11-8 |
|---|---|
| Chemical Name | 2-Benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| SMILES | C1(Cl)C=CC(C2C(CC3C=CC=CC=3)=NN3C(=O)C=C(C4C=CC([N+]([O-])=O)=CC=4)NC=23)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H17ClN4O3/c26-19-10-6-18(7-11-19)24-22(14-16-4-2-1-3-5-16)28-29-23(31)15-21(27-25(24)29)17-8-12-20(13-9-17)30(32)33/h1-13,15,27H,14H2 |
| InChiKey | GUUWHOSUKOCRHG-UHFFFAOYSA-N |
| CID | 2257249 |
| Short Description | Arf1/Arf6/FATP2 inhibitor |
NAV-2729
Arf1/Arf6/FATP2 inhibitor
Grassofermata
NAV2729
NAV 2729
CB5
CB 5
CB-5
CAS 419547-11-8
CAS 1219832-51-5
Axon Medchem
Axon 3622
GTP
Arf
Inhibitor
Enzymes
Fatty acid transport protein
Obesity
Type 2 diabetes
Coronary heart disease
SLC27A2
Very long-chain acyl-CoA synthetase
VLACS
ADP-ribosylation factor 6
Supplier
Vendor
References
- A Sandoval et al. Identification and characterization of small compound inhibitors of human FATP2. Biochem Pharmacol. 2010 Apr 1;79(7):990-9.
- Y Yamauchi et al. Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs. Adv Biol Regul. 2017 Jan;63:115-121.
- S Benabdi et al. Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles. Biochemistry. 2017 Sep 26;56(38):5125-5133.
