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CD38 inhibitor compound 78c
- CD38i 78c
Axon 3570
CAS:
1700637-55-3
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C22H27N3O3S
- MW: 413.53
Description
CD38 inhibitor compound 78c is a potent, specific, reversible, and uncompetitive inhibitor of CD38 with IC50 values of 7.3 nM and 1.9 nM for human and mice, respectively. Compound 78c was given to diet induced obese (DIO) C57Bl6 mice, elevating NAD > 5-fold in liver and >1.2-fold in muscle versus control animals at a 2 h time point. Moreover, Compound 78c reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging.
More Information
| Parent CAS No. | 1700637-55-3 |
|---|---|
| Chemical Name | 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone |
| MFCD | N.A. |
| Short Description | CD38 inhibitor |
References
- CD Haffner et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71.
- MG Tarragó et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018 May 1;27(5):1081-1095.e10.
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