CD38 inhibitor compound 78c - CD38i 78c

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3570

CAS [1700637-55-3]

MF C22H27N3O3S
MW 413.53

  • Purity: 99%
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
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CD38 inhibitor compound 78c

Description

CD38 inhibitor compound 78c is a potent, specific, reversible, and uncompetitive inhibitor of CD38 with IC50 values of 7.3 nM and 1.9 nM for human and mice, respectively. Compound 78c was given to diet induced obese (DIO) C57Bl6 mice, elevating NAD > 5-fold in liver and >1.2-fold in muscle versus control animals at a 2 h time point. Moreover, Compound 78c reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging.

KEYWORDS: CD38 inhibitor compound 78c | Supplier | CD38 inhibitor | CD38i 78c | CAS [1700637-55-3] | Glycosides | NADase | Inhibitor | Enzymes | ADP ribosyl cyclase | Nicotinamide adenine dinucleotide | NAD+

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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