JavaScript seems to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.

Axon Medchem

All

Home
Products
- Shop By Category
- Featured Products
- Shop By Alphabet
  - A
  - B
  - C
  - D
  - E
  - F
  - G
  - H
  - I
  - J
  - K
  - L
  - M
  - N
  - O
  - P
  - Q
  - R
  - S
  - T
  - U
  - V
  - W
  - X
  - Y
  - Z
  - #
Support
- - Customer Support
  - Customer Services
Contact
- About Axon Medchem
- Contact Us

Home
Products
Enzymes
Hydrolases
Deaminases
GSK484 hydrochloride

GSK484 hydrochloride

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 3531

CAS [1652591-81-5]

MF C27H31N5O3.HCl
MW 510.03

Purity: 98%
Optical purity: Optically pure
Soluble in water, DMSO and EtOH

GSK484 hydrochloride

Description

GSK484 hydrochloride is a highly potent, selective, and reversible PAD4 inhibitor with an IC50 value of 50 nM (in the absence of calcium).

KEYWORDS: GSK484 hydrochloride | Supplier | PAD4 inhibitor | GSK 484 hydrochloride | GSK-484 hydrochloride | CAS [1652591-81-5] | [1652629-23-6] | Protein L-arginine | PAD | Inhibitor | Enzymes | Immunology | NETosis | PADI4 | Oncology | Neutrophil extracellular traps | Innate immunity | Protein arginine deiminase

HD Lewis et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91.

Cell Signaling & Oncology Immunology EC 3.5.3.15

Highly potent, selective, and reversible PAD4 inhibitor

Chemical name

((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

Parent CAS No.

[1652629-23-6]

Order

Size	Unit Price	Stock
5 mg	€150.00	In Stock
25 mg	€520.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€240.00	In Stock

Need more? Bulk Inquiry

Please wait...