RO-0711401

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3422

CAS [714971-87-6]

MF C18H11F3N2O3
MW 360.29

Purity: 99%
Soluble in DMSO

RO-0711401

Description

RO-0711401 is a potent and orally available positive allosteric modulator (PAM) of the mGlu1 receptor with an IC50 value of 56 nM.

E Vieira et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9.

PM Garcia-Barrantes et al. Re-exploration of the mGlu₁ PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR. Bioorg Med Chem Lett. 2016 May 1;26(9):2289-92.

Potent and orally available PAM of mGluR1

Chemical name

N-(4-(Trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide

Parent CAS No.

[714971-87-6]

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Size	Unit Price	Stock
5 mg	€90.00	In Stock
25 mg	€270.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€420.00	In Stock

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RO-0711401

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