CB096

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 3393

CAS [108883-90-5]

MF C14H11N3O4
MW 285.25

  • Purity: 99%
  • Soluble in DMSO
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CB096

Description

CB096 selectively inhibited repeat associated non-ATG (RAN) translation and decreased the production of poly(GP) DPRs without affecting r(G4C2)66 mRNA levels in an HEK293T cellular model of c9ALS/FTD, alleviated dysfunctional nucleocytoplasmic transport, and selectively reduced the abundance of r(G4C2)66-induced stress granules. Moreover, CB096 is a selective binder to the r(G4C2)8 hairpin over r(G2C4)8 (antisense), r(GGCC)10 (base pair) RNAs, and other 1×1 internal loops.

KEYWORDS: CB096 | Supplier | RAN inhibitor | CB 096 | CB-096 | CAS [108883-90-5] | DNA-RNA | RAN | Inhibitor | Hypertension | Amyotrophic lateral sclerosis | ALS | Frontotemporal dementia | FTD

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Size Unit Price Stock
10 mg €110.00 In Stock
50 mg €330.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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