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CB096
- Soluble in DMSO
- MF: C14H11N3O4
- MW: 285.25
Description
CB096 selectively inhibited repeat associated non-ATG (RAN) translation and decreased the production of poly(GP) DPRs without affecting r(G4C2)66 mRNA levels in an HEK293T cellular model of c9ALS/FTD, alleviated dysfunctional nucleocytoplasmic transport, and selectively reduced the abundance of r(G4C2)66-induced stress granules. Moreover, CB096 is a selective binder to the r(G4C2)8 hairpin over r(G2C4)8 (antisense), r(GGCC)10 (base pair) RNAs, and other 1×1 internal loops.
More Information
| Parent CAS No. | 108883-90-5 |
|---|---|
| Chemical Name | 2-Methoxy-4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenol |
| SMILES | C1([N+]([O-])=O)C=C2N=C(C3C=CC(O)=C(OC)C=3)NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H11N3O4/c1-21-13-6-8(2-5-12(13)18)14-15-10-4-3-9(17(19)20)7-11(10)16-14/h2-7,18H,1H3,(H,15,16) |
| InChiKey | LSNPOGOZVAHETR-UHFFFAOYSA-N |
| CID | 4460926 |
| Short Description | RAN inhibitor |
References
- G Navarrete-Vázquez et al. Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives. Bioorg Med Chem. 2010 Jun 1;18(11):3985-91.
- A Ursu et al. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Dec 18;15(12):3112-3123.
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