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6-Thioguanine
Axon 3253
CAS:
154-42-7
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C5H5N5S
- MW: 167.19
Description
6-Thioguanine, a thiopurine-derivative, is metabolized in active forms which are incorporated into RNA and DNA, respectively, as fraudulent bases. Incorporation into DNA results into a stop of replication by single-strand breaks, crosslinking and sister chromatid exchange. Immunosuppresant.
More Information
| Parent CAS No. | 154-42-7 |
|---|---|
| Chemical Name | 2-Amino-1H-purine-6(9H)-thione |
| SMILES | N1C(=S)C2N=CNC=2N=C1N |
| MFCD | MFCD00233553 |
| InChi | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) |
| InChiKey | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| CID | 2723601 |
| Short Description | Purine analog |
6-Thioguanine
Purine analog
CAS 154-42-7
CAS 76078-67-6
Axon Medchem
Axon 3253
Immunology
Non Selective
Suppresant
Antimetabolite drug
Leukemia
Immune-inflammatory disease
Psoriasis
SLE
Polycythemia vera
Churg-Strauss syndrome
IBD
Collagenous sprue
Refractory celiac disease
Autoimmune hepatitis
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