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RA375
Axon 3210
CAS:
2649154-57-2
- Optical Purity: 98.4% e.e.
- Soluble in DMSO
- MF: C30H25ClN4O7
- MW: 589
Description
RA375 is a potent RPN13 inhibitor with IC50 values of 13 and 26 nM against HeLa and SKOV3 cells, respectively. Treatment with RA375 caused a rapid and profound accumulation of high molecular weight polyubiquitinated proteins and reduced intracellular glutathione levels, which produce endoplasmic reticulum and oxidative stress, and trigger apoptosis.
More Information
| Parent CAS No. | 2649154-57-2 |
|---|---|
| Chemical Name | N-((S)-1-((3E,5E)-3,5-Bis(4-Nitrobenzylidene)-4-oxopiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-chloroacetamide |
| SMILES | C1C=C(/C=C2/C(=O)/C(=C/C3C=CC([N+]([O-])=O)=CC=3)/CN(C([C@@H](NC(=O)CCl)CC3C=CC=CC=3)=O)C/2)C=CC=1[N+]([O-])=O |&1:21,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H25ClN4O7/c31-17-28(36)32-27(16-20-4-2-1-3-5-20)30(38)33-18-23(14-21-6-10-25(11-7-21)34(39)40)29(37)24(19-33)15-22-8-12-26(13-9-22)35(41)42/h1-15,27H,16-19H2,(H,32,36)/b23-14+,24-15+/t27-/m0/s1 |
| InChiKey | REFAVUFYPFWJGH-SWAPHQFDSA-N |
| CID | 146681207 |
| Short Description | RPN13 inhibitor |
