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RA-190

Axon 4476
  • Parent CAS:  1617572-02-7
  • Optical Purity:  Optically pure
  • Soluble in DMSO and EtOH
  • MF:  C28H22Cl4N2O2·HCl
  • MW:  596.76

Description

RA-190 is a potent, orally available proteasome inhibitor which covalently binds to cysteine 88 of human proteasomal ubiquitin receptor RPN13, triggering rapid accumulation of polyubiquitinated proteins.

More Information

Parent CAS No. 1617572-02-7
Chemical Name 3,5-Bis(3,4-dichlorobenzylidene)-1-(S-2-amino-3-phenyl)-piperidin-4-one hydrochloride
SMILES C1=C(/C=C2/C(=O)/C(=C/C3=CC(Cl)=C(Cl)C=C3)/CN(C([C@@H](N)CC3=CC=CC=C3)=O)C/2)C=CC(Cl)=C1Cl.Cl |&1:19,r|
MFCD MFCD30738021
InChi InChI=1/C28H22Cl4N2O2.ClH/c29-22-8-6-18(12-24(22)31)10-20-15-34(28(36)26(33)14-17-4-2-1-3-5-17)16-21(27(20)35)11-19-7-9-23(30)25(32)13-19;/h1-13,26H,14-16,33H2;1H/b20-10+,21-11+;/t26-;/s3
InChiKey UMWXLEVUBFNYIK-OHKGUDSUNA-N
CID 126843229
Short Description RPN13 inhibitor

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