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DS45500853
- Soluble in DMSO and EtOH
- MF: C18H20O3
- MW: 284.35
Description
DS45500853 is a synthetic agonist of the orphan nuclear receptor estrogen-related receptor α (ERRα). It inhibits the interaction between ERRα and the coregulator RIP140 with an assay IC50 value of 0.80 µM and activates an ERRα-responsive reporter with an EC50 value of 5.4 µM, while showing little detectable PPARγ transcriptional activity.
DS45500853 is used to examine ERRα-dependent transcription, coactivator and corepressor exchange, mitochondrial metabolism and energy-homeostasis programs. Its separation from PPARγ activity makes it useful for distinguishing ERRα-mediated metabolic responses from those driven by closely related nuclear-receptor pathways.
Key Features
- ERRα agonist and transcriptional activator
- IC50: 0.80 µM in the ERRα–RIP140 interaction assay
- Reporter EC50: 5.4 µM
- Minimal reported PPARγ transcriptional activity
Applications
- ERRα nuclear-receptor studies
- Coregulator-interaction assays
- Mitochondrial and oxidative-metabolism research
- Nuclear-receptor selectivity profiling
More Information
| Parent CAS No. | 2735803-28-6 |
|---|---|
| Chemical Name | 1-(4-(3-tert-Butyl-4-hydroxyphenoxy)phenyl)ethanone |
| SMILES | C1(O)C=CC(OC2C=CC(C(=O)C)=CC=2)=CC=1C(C)(C)C |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20O3/c1-12(19)13-5-7-14(8-6-13)21-15-9-10-17(20)16(11-15)18(2,3)4/h5-11,20H,1-4H3 |
| InChiKey | WSVZSZVSZTYTCC-UHFFFAOYSA-N |
| CID | 155926635 |
| Short Description | ERRα agonist |
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