ML2-SA1 is a potent, selective and efficacious activator of TRPML2 with EC50 values of 1.24 μM and 2.38 μM for human and mouse TRPML2, respectively. ML2-SA1 shows high selectivity over h/mTRPML1 and h/mTRPML3 in both calcium imaging and endolysosomal patch-clamp experiments and it does not activate TPC1 nor TPC2.

KEYWORDS: ML2-SA1 | supplier | TRPML2 activator | EVP-22 | ML2SA1 | ML2 SA1 | EVP22 | EVP 22 | CAS [N.A.] | Non Selective (Cations) | TRPML | Activator | Ion Channels | MCOLN2 | Innate immune response