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ML2-SA1
- EVP-22
- Soluble in DMSO
- MF: C14H13Cl2NO
- MW: 282.17
Description
ML2-SA1 is a potent, selective and efficacious activator of TRPML2 with EC50 values of 1.24 μM and 2.38 μM for human and mouse TRPML2, respectively. ML2-SA1 shows high selectivity over h/mTRPML1 and h/mTRPML3 in both calcium imaging and endolysosomal patch-clamp experiments and it does not activate TPC1 nor TPC2.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | 5-(2,6-Dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene |
| SMILES | C1C2CC(C3C(C4C(Cl)=CC=CC=4Cl)=NOC32)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2 |
| InChiKey | NBXVMFMMTKYFQP-UHFFFAOYSA-N |
| CID | 137553170 |
| Short Description | TRPML2 activator |
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