BI 01383298 is a potent and selective inhibitor of SLC13A5 with an apparent IC50 value of 56 nM in HEK cells overexpressing SLC13A5 and 24nM in HepG2 cell expressing endogenous SLC13A5. BI 01383298 is more than 1000-fold selective over the closest family members: human SLC13A2/SLC13A3 that share physiological substrates citrate and succinate; chemical probe developed by SGC.

KEYWORDS: BI 01383298 | supplier | SLC13A5 inhibitor | BI01383298 | BI-01383298 | CAS [2227549-00-8] | Citric acid | Na+/citrate cotransporter | Inhibitor | Proteins | SGC