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CD12681

Axon 2964
CAS:  1952239-59-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C25H33N3O4S
  • MW:  471.61

Description

CD12681 is a potent RORγ inverse agonist with an IC50 value of 19 nM. CD12681 showed in vivo activity in an IL-23 induced skin inflammation model in mouse. Preclinical candidate for the topical treatment of psoriasis.

More Information

Parent CAS No. 1952239-59-6
Chemical Name N-(2,4-Dimethylphenyl)-N-isobutyl-2-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide
SMILES C12NC(=O)N(CC3CCOCC3)C=1C=CC(S(=O)(=O)N(C1C(C)=CC(C)=CC=1)CC(C)C)=C2
MFCD N.A.
InChi InChI=1S/C25H33N3O4S/c1-17(2)15-28(23-7-5-18(3)13-19(23)4)33(30,31)21-6-8-24-22(14-21)26-25(29)27(24)16-20-9-11-32-12-10-20/h5-8,13-14,17,20H,9-12,15-16H2,1-4H3,(H,26,29)
InChiKey RZXJZXXYHNBHNX-UHFFFAOYSA-N
CID 121427905
Short Description RORγ agonist

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