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JNJ 47965567

Axon 2890
CAS:  1428327-31-4
Purity:  99%
  • Soluble in DMSO
  • MF:  C28H32N4O2S
  • MW:  488.64

Description

JNJ-47965567 is a potent, selective and brain-penetrant antagonist of the ATP-gated P2X7 receptor. Reported pKi values are 7.9 at human P2X7, 7.9 at rat P2X7 and 6.9 in a human whole-blood assay.

JNJ-47965567 blocks P2X7-dependent pore formation, inflammasome-associated cytokine release and neuroimmune signaling and has suitable pharmacokinetic properties for in vivo target-occupancy studies. It is used to investigate P2X7 function in microglia, neuroinflammation, pain and inflammatory disease models.

Key Features

  • Potent P2X7 receptor antagonist
  • pKi: 7.9 at human and rat P2X7
  • Brain-penetrant
  • Suitable for in vivo pharmacodynamic studies
  • Blocks P2X7-dependent inflammatory signaling

Applications

  • P2X7 receptor pharmacology
  • Microglial activation studies
  • Inflammasome and cytokine-release assays
  • Neuroinflammation models
  • Pain and inflammatory disease research

More Information

Parent CAS No. 1428327-31-4
Chemical Name N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide
SMILES C1C=C(C(NCC2(N3CCN(C4C=CC=CC=4)CC3)CCOCC2)=O)C(SC2C=CC=CC=2)=NC=1
MFCD MFCD28334214
InChi InChI=1S/C28H32N4O2S/c33-26(25-12-7-15-29-27(25)35-24-10-5-2-6-11-24)30-22-28(13-20-34-21-14-28)32-18-16-31(17-19-32)23-8-3-1-4-9-23/h1-12,15H,13-14,16-22H2,(H,30,33)
InChiKey XREFXUCWSYMIOG-UHFFFAOYSA-N
CID 66553218
Short Description P2X7 antagonist

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