EN460 - ERO1 Inhibitor II

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2737

CAS [496807-64-8]

MF C22H12ClF3N2O4
MW 460.79

  • Purity: 99%
  • Soluble in DMSO



EN460, an inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50 value of 1.9 μM). Despite rapid and promiscuous reactivity with thiolates, EN460 exhibits selectivity for ERO1.

KEYWORDS: EN460 | supplier | ERO1 inhibitor | ERO1 Inhibitor II | EN 460 | EN-460 | CAS [496807-64-8] | Protein Disulfide Isomerase (PDI) | ERO1 | Inhibitor | Enzymes | Endoplasmic Reticulum Oxidation

Inhibitor of endoplasmic reticulum oxidation 1 (ERO1)

Chemical name

(Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Parent CAS No.


Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €275.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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