STAT5 Inhibitor 1 [285986-31-4]

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2731

CAS [285986-31-4]

MF C16H11N3O3
MW 293.28

Purity: 98%
Soluble in DMSO

STAT5 Inhibitor 1 [285986-31-4]

Description

STAT5 Inhibitor 1 [285986-31-4] is a first nonpeptidic small-molecule which selectively inhibits the function of the STAT5b domain (IC50 value of 47 μM), STAT5 DNA binding in vitro, and activation of STAT5 in a cancer cell line. Also selective impairment of STAT5 phosphorylation with STAT5 Inhibitor 1 markedly reduced iTregs.

J Müller et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7.

BC Betts et al. STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity. J Leukoc Biol. 2014 Feb;95(2):205-13.

Apoptosis Cell Signaling & Oncology Immunology Transcription Factors JAK-STAT TF class 4.2.1 STAT5

Nonpeptidic small-molecule inhibitor of STAT5 activation

Chemical name

N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

Parent CAS No.

[285986-31-4]

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STAT5 Inhibitor 1 [285986-31-4]

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