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L67
- Soluble in DMSO
- MF: C16H14Br2N4O4
- MW: 486.11
Description
Cytotoxic inhibitor of DNA ligase I and III (IC50 values 10 μM each) that binds to the DBD of hLigI, hence leading to inhibition of DNA binding and ligation and specifically sensitizes cancer cells to DNA damage. Breast cancer cell lines with acquired resistance to antiestrogen therapeutics are hypersensitive to a combination of L67 and PARP inhibitor ABT 888 (Axon 1593).
More Information
| Parent CAS No. | 325970-71-6 |
|---|---|
| Chemical Name | 2-(3,5-dibromo-4-methylphenylamino)-N'-(2-hydroxy-5-nitrobenzylidene)acetohydrazide |
| SMILES | C1(C)C(Br)=CC(NCC(=O)N/N=C/C2C(O)=CC=C([N+]([O-])=O)C=2)=CC=1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+ |
| InChiKey | KFEPVFJQVOMODD-IFRROFPPSA-N |
| CID | 135419707 |
| Short Description | DNA ligase inhibitor |
References
- X Chen et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.Cancer Res. 2008 May 1;68(9):3169-77.
- LA Tobin et al. Targeting abnormal DNA repair in therapy-resistant breast cancers. Mol Cancer Res. 2012 Jan;10(1):96-107.
- DK Singh et al. Human DNA ligases: a comprehensive new look for cancer therapy. Med Res Rev. 2014 May;34(3):567-95.
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