Suppressor of superoxide production from mitochondrial complex III (IC50 value 1.7 µM against superoxide production mediated by the outer Q-binding site of complex III (site IIIQo)). S3QEL-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells, and strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets. S3QEL-2 modulates HIF-1α activation without directly affecting metabolism.

KEYWORDS: S3QEL 2 | supplier | Complex III modulator | S3QEL2 | CAS [890888-12-7] | Quinol | Complex III | Coenzyme Q | superoxide | ROS | mitochondria | Q-binding site | site III Qo | oxidative stress | reactive oxygen species