Noncompetitive, allosteric antagonist of human P2X4 receptor channels (IC50 value 0.54 μM as determined by Patch-clamp electrophysiology) with 10-100 fold selectivity over P2X1–P2X3, P2X5, and P2X7. A useful molecular probe to assess the specific role of P2X4 in inflammatory and neuropathic conditions, where ATP signaling has been shown to be dysfunctional. BX430 has no effect on mouse and rat P2X4Rs.

KEYWORDS: BX 430 | supplier | P2X4 antagonist | BX430 | CAS [688309-70-8] | Calcium | P2X4 | Ion Channel | P2X | cation | inflammation | ATP | pain | purinoceptor | vasodilation | patch clamp | current