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BX 430
Axon 2523
CAS:
688309-70-8
Purity:
99%
- Soluble in DMSO
- MF: C15H15Br2N3O
- MW: 413.11
Description
BX 430 is a noncompetitive allosteric antagonist of human P2X4 receptor channels. It blocks ATP-gated cation flux with selectivity over several other P2X receptor subtypes.
P2X4 receptors regulate purinergic signaling in immune cells, microglia, vascular tissues and pain pathways. BX 430 is useful for studying P2X4-selective pharmacology, ATP-gated ion-channel function and neuroimmune signaling.
Key Features
- P2X4 receptor antagonist
- Reported IC50: 0.54 µM by patch-clamp electrophysiology
- Noncompetitive allosteric inhibition profile
- Reported 10-100-fold selectivity over P2X1-3, P2X5 and P2X7
Applications
- P2X4 purinergic receptor pharmacology
- ATP-gated ion-channel assays
- Neuroinflammation and microglial signaling studies
- Pain and immune-cell pathway research
More Information
| Parent CAS No. | 688309-70-8 |
|---|---|
| Chemical Name | 1-(2,6-dibromo-4-isopropylphenyl)-3-(pyridin-3-yl)urea |
| SMILES | N(C1=C(Br)C=C(C(C)C)C=C1Br)C(NC1=CC=CN=C1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21) |
| InChiKey | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| CID | 2810999 |
| Short Description | P2X4 antagonist |
References
- A.R. Ase et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16.
- K.A. Jacobson et al. Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology. 2015 Dec 12. pii: S0028-3908(15)30197-0. doi: 10.1016/j.neuropharm.2015.12.001.
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