Chloroquine diphosphate - NSC 14050

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2431

CAS [50-63-5]

MF C18H26ClN3.2H3PO4
MW 515.86

  • Purity: 99%
  • Soluble in water

Chloroquine diphosphate


Classical antimalarial drug (CQ) with lysosomotropic effects causing necrosis and apoptosis. Inhibitor of hemozoin (β-​hematin) formation in malaria (Plasmodium strains) affected red blood cells. Nowadays, most of the Plasmodium falciparum strains are resistant to this drug. Chloroquine was found to inhibit the human thiamine transporter ThTr-2 (SLC19A3), and to inhibit cell growth and to induce cell death in A549 lung cancer cells.

*Drug Reference Standard Grade

KEYWORDS: Chloroquine diphosphate | supplier | Antimalarial drug | NSC 14050 | NSC14050 | CQ | CAS [50-63-5] | [54-05-7] | beta-hematin | Plasmodium | hemoglobin | hemozoin | thiamine | transporter | ThTr-2 | SLC19A3 | apoptosis | necrosis

Caution: Axon Ligands™ are for research purposes only! Not intended for human consumption!

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50 mg €40.00 In Stock
250 mg €80.00 In Stock
1000 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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