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BEC hydrochloride
- S-(2-Boronoethyl)-L-cysteine hydrochloride
- Parent CAS: 63107-40-4
- Soluble in water and DMSO
- MF: C5H12BNO4S.HCl
- MW: 229.49
Description
Slow-binding pH-dependent inhibitior of human Arginase I and II (Kd value 270 nM and 220 nM for Arginase I and II, respectively. Ki values 310 nM and 30 nM at pH 7.5 and pH 9.5, respectively for Arginase II). Valuable reagent to probe the physiological relationship between arginase and nitric oxide (NO) synthase in regulating the NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
BEC Does not inhibit NO synthase, and effectively prevented ACh tolerance in aortic and mesenteric artery preparations.
More Information
| Parent CAS No. | 63107-40-4 |
|---|---|
| Chemical Name | (R)-2-Amino-3-(2-boronoethylthio)propanoic acid hydrochloride |
| MFCD | MFCD03453539 |
| Short Description | Arginase inhibitor |
References
- N.N. Huynh et al. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br. J. Pharmacol. 2009, 156, 84-93.
- S.M. Khong et al. Arginase II inhibition prevents nitrate tolerance. Br J Pharmacol. 2012, 166, 2015-2023.
- D.M. Colleluori et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001, 40, 9356-9362.
- N.N. Kim et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001, 40, 2678-2688.
- L. Di Costanzo et al. Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc. Natl. Acad. Sci. USA. 2005, 102, 13058-13063.
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