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TH 287 hydrochloride
Axon 2271
- Parent CAS: 1609960-30-6
Purity:
98%
- Soluble in DMSO
- MF: C11H10Cl2N4.HCl
- MW: 305.59
Description
First-in-class MTH1 inhibitor (IC50 value 0.8 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.
TH 287 shows no relevant inhibitory effect for any of the other tested nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, nor for other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase and ITPA).
More Information
| Parent CAS No. | 1609960-30-6 |
|---|---|
| Chemical Name | 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride |
| SMILES | C1C(C2C=CC=C(Cl)C=2Cl)=NC(N)=NC=1NC.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C11H10Cl2N4.ClH/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13;/h2-5H,1H3,(H3,14,15,16,17);1H |
| InChiKey | YBLIJWDQSUDCJU-UHFFFAOYSA-N |
| CID | 91826506 |
| Short Description | MTH1 inhibitor |
References
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