SB 269970 hydrochloride - SB 269970A

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2183

CAS [261901-57-9]

MF C18H28N2O3S.HCl
MW 388.95

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

SB 269970 hydrochloride

Description

Potent and selective 5-HT7 antagonist (pKi value 8.9 for 5-HT7a) with >50 fold selectivity over a wide range of serotonergic, dopaminergic and adrenergic receptors. Analogue of SB 258741 hydrochloride (Axon 1100).
SB 269970 significantly blocked amphetamine and ketamine-induced hyperactivity and reversed amphetamine-induced but not ketamine-induced prepulsed inhibiton (PPI) deficits, without changing spontaneous locomotor activity and startle amplitude.

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10 mg €110.00 In Stock
50 mg €380.00 In Stock
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2 x 10 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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