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Axon 2183
CAS [261901-57-9]
MF C18H28N2O3S.HClMW 388.95
Potent and selective 5-HT7 antagonist (pKi value 8.9 for 5-HT7a) with >50 fold selectivity over a wide range of serotonergic, dopaminergic and adrenergic receptors. Analogue of SB 258741 hydrochloride (Axon 1100). SB 269970 significantly blocked amphetamine and ketamine-induced hyperactivity and reversed amphetamine-induced but not ketamine-induced prepulsed inhibiton (PPI) deficits, without changing spontaneous locomotor activity and startle amplitude.
(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol hydrochloride
[201038-74-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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