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Avridine
- CP 20961
Axon 2099
CAS:
35607-20-6
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C43H90N2O2
- MW: 667.19
Description
Avridine (CP 20961) is a lipoidal amine immunomodulator with interferon-inducing and adjuvant activity. It has been used to enhance immune responses to Newcastle disease antigen and to induce adjuvant arthritis in susceptible rat strains.
Avridine is pharmacologically relevant as an innate immune activation tool for studying vaccine adjuvanticity, cytokine induction, inflammatory arthritis and host immune modulation.
Key Features
- Lipoidal amine with immunomodulatory activity
- Induces interferon-associated immune responses
- Acts as an adjuvant in antigen-response models
- Can induce adjuvant arthritis in rat inflammation studies
Applications
- Vaccine adjuvant research
- Innate immune activation studies
- Inflammatory arthritis model development
- Cytokine and interferon biology
More Information
| Parent CAS No. | 35607-20-6 |
|---|---|
| Chemical Name | 2,2'-(3-(dioctadecylamino)propylazanediyl)diethanol |
| extra_info | . |
| SMILES | N(CCO)(CCO)CCCN(CCCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCCC |
| MFCD | MFCD00673242 |
| InChi | InChI=1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3 |
| InChiKey | WXNRAKRZUCLRBP-UHFFFAOYSA-N |
| CID | 37186 |
| Short Description | NDA Adjuvant |
References
- NF Pierce & JB Sacci. Enhanced mucosal priming by cholera toxin and procholeragenoid with a lipoidal amine adjuvant (avridine) delivered in liposomes. Infection and immunity, 1984, 44(2), 469-473.
- MM Rweyemamu et al. Efficacy of avridine as an adjuvant for Newcastle disease virus antigen in chickens. Am. J. Veterinary Res. 1986, 47(6), 1243-1248.
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