Avridine (Axon 2099), for example, is a lipoidal amine with interferon-inducing and adjuvant properties specifically related to Newcastle disease. What’s more, although avridine is a synthetic non-immunogenic adjuvant, it is also known to induce arthritis in rats in a predictable and T-cell dependent way. However, the mechanism of action by which this Avridine Induced Arthritis (AvIA) is triggered, or acts as adjuvant of the Newcastle disease antigen has not been elucidated in detail but is hypothesized to mediated by interferon (IFN).
 M.M. Rweyemamu et al. Efficacy of avridine as an adjuvant forNewcastle disease virus antigen in chickens. Am. J. Vet. Res. 1986, 47, 1243-1248.
 C. Vingsbro, R. Jonsson, R. Holmdahl. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both byMHC genes and by non-MHC genes. Clin Exp Immunol 1995, 99, 359-363.