CID 11654378 - FMS inhibitor compound 8 | FMS inhibitor compound 1b

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2061

CAS [885704-21-2]

MF C23H30N6O
MW 406.52

Purity: 99%
Soluble in DMSO

CID 11654378

Description

A highly potent FMS kinase inhibitor (IC50 = 0.8 nM); a proof-of-concept candidate in a collagen-induced model of arthritis in mice

CR Illig et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorg. Med. Chem. Lett. 2008, 18(5), 1642-1648.

SK Meegalla et al. Structure-based optimization of a potent class of arylamide FMS inhibitors. Bioorg. Med. Chem. Lett. 2008, 18(12), 3632-3637.

Cell Signaling & Oncology Pain & Inflammation FMS RTK class III; EC 2.7.10.1

Potent FMS kinase inhibitor

Chemical name

4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide

Parent CAS No.

[885704-21-2]

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CID 11654378 - FMS inhibitor compound 8 | FMS inhibitor compound 1b

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CID 11654378 - FMS inhibitor compound 8 | FMS inhibitor compound 1b

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