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(R)-6-Hydroxybuspirone hydrochloride
- BMS 442608 hydrochloride
Axon 1997
- Parent CAS: 477930-30-6
Purity:
99%
- Soluble in water and DMSO
- MF: C21H31N5O3.HCl
- MW: 437.96
Description
Optically pure (R)-enantiomer of 6-hydroxybuspirone (Axon 1996), a major active metabolite of Buspirone (Axon 1995); 5-HT1A partial agonist. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer
More Information
| Parent CAS No. | 477930-30-6 |
|---|---|
| Chemical Name | (R)-6-hydroxy-8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
| MFCD | N.A. |
| Short Description | 5-HT1A agonist |
References
- H Wong et al. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug Metab. Dispos. 2007, 35(8), 1387-1392.
- RC Dockens et al. Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans. Biopharm. Drug Dispos. 2007, 28(7), 393-402.
- SJ Nicholson et al. Development of oral extended release formulations of 6-hydroxybuspirone. Biopharm. Drug Dispos. 2012, 33(9), 522-535.
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