Bulk Inquiry
BXL 628
- Elocalcitol - RO 26-9228
Axon 1676
CAS:
199798-84-0
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C29H43FO2
- MW: 442.65
Description
A vitamin D3 analog having agonistic activities at vitamin D receptor (VDR); BXL-628 inhibits prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway; having anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment
More Information
| Parent CAS No. | 199798-84-0 |
|---|---|
| Chemical Name | (1R,5S,Z)-3-((E)-2-((3aS,7aS)-3-((S,E)-6-ethyl-6-hydroxyoct-4-en-2-yl)-3a-methyl-3a,4,5,6-tetrahydro-1H-inden-7(7aH)-ylidene)ethylidene)-5-fluoro-4-methylenecyclohexanol |
| SMILES | C1[C@H](O)C/C(=C/C=C2/[C@]3([H])CC=C([C@@H](C)C/C=C/C(CC)(O)CC)[C@@]3(C)CCC/2)/C(=C)[C@H]1F |&1:1,8,13,24,31,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C29H43FO2/c1-6-29(32,7-2)17-8-10-20(3)25-14-15-26-22(11-9-16-28(25,26)5)12-13-23-18-24(31)19-27(30)21(23)4/h8,12-14,17,20,24,26-27,31-32H,4,6-7,9-11,15-16,18-19H2,1-3,5H3/b17-8+,22-12+,23-13-/t20-,24+,26-,27-,28+/m0/s1 |
| InChiKey | LRLWXBHFPGSUOX-GJQYOBCGSA-N |
| CID | 11396600 |
| Short Description | VDR agonist |
References
- C Crescioli et al. Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia. Eur. J. Endocrinol. 2004, 150(4), 591-603.
- E Colli et al. BXL628, a novel vitamin D3 analog arrests prostate growth in patients with benign prostatic hyperplasia: a randomized clinical trial. Eur Urol. 2006, 49(1), 82-86.
- A Morelli et al. BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder. Prostate. 2007, 67(3), 234-247.
- G Penna et al. The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways. Prostate. 2009, 69(5), 480-493.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1746 | Doxercalciferol |
From $110.00 |
| 2331 | FRAX 486 |
From $99.00 |
| 2516 | Tacalcitol |
From $181.50 |
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.